Since you can’t influence the odds in your favor at Keno, there is really no winning strategy. However, always bear in mind that you’ll win more frequently if you choose few numbers, which correspondingly have lower payoffs; and you’ll stand a chance to win bigger payouts when you pick more numbers, which dramatically increase the odds against your winning (see The Odds).

In brief, pick an approach to Keno that best suits the way you’re most likely to have fun, and the amount of money you are prepared to safely wager.